細胞生物化學和生物物理學促進理解控制細胞生理穩態的生物化學和生物物理機制的本質及其擾動的后果。報告跨越學科的現代生物化學和化學，生物物理學和細胞生理學，物理和工程，分子和結構生物學和醫學。重點放在分子結構與所研究的特定性質/功能之間的關系。CBB發表文章描述定量利用和創新發展:基因和生物分子工程;組織、細胞、細胞網絡、細胞器和分子/大分子組件的計算機分析;研究和發展分析細胞學和細胞術的光度學、光譜學、顯微學、機械和電子方法/技術，以及儀器設計方面的創新。

Cell Biochemistry and Biophysics fosters progress in comprehending the nature of the biochemical and biophysical mechanisms underlying the control of cellular physiological homeostasis and the consequences of its perturbation. Reports span the disciplines of modern biochemistry and chemistry, biophysics and cell physiology, physics and engineering, molecular and structural biology and the medical sciences. Emphasis is placed on the relationship between molecular structure and the nature of the specific property/function under investigation. CBB publishes articles describing the quantitative utilization of and innovative developments in: genetic and biomolecular engineering; computer analysis of tissues, cells, cell networks, organelles, and molecular/macromolecular assemblies; research in and development of photometric, spectroscopic, microscopic, mechanical, and electrical methodologies/techniques in analytical cytology and cytometry, as well as innovation in instrument design.